The disease, which collectively collibacillosis caused by primary or secondary infections caused by E. coli. E. coli is serologically infected by pathogenic E. coli from normal intestinal flora in mammals and birds, and secondarily to other disease cause mixed infections because there are cases showing the variety of symptoms.
1. Agent
 E.coli
2. Epidemiology
① subsequently break through the egg shell by fecal E. coli contamination of the egg surface.
② dust in poultry house, dry conditions to survive for more than humid conditions in the long term.
③ propagates through the feed contaminated with the E. coli.
④ is introduced into the flock of a rodent feces, through the polluted water in the well .
 
3. Clinical Signs
At infection of the respiratory system, IBV, NDV and mycoplasma as acomplex disease are common. Especially respiratory the damaged by a variety of environmental factors is to facilitate the attack by the E. coli flowing through the respiratory tract. This aspect is often infected with the disease is also called CCRD.
 
1) Air Sacculitis
① often occurs mainly in chickens are 5-12 weeks of age, and occurs mostly when 6-9 weeks of age.
② is exacerbated by breathing the dust and poor air inside the cage.
③ mycoplasma, IB, ND, and ILT primary viral infections such as E. coli is a secondary infection.
④ inflammation is occurring in the air sac and in severe cases the function of the sac is disturbed by exudate.

 
 
2) Pericarditis
① it is going to cause acute sepicemia after pericarditis and mortality.
② pericardium is turbid and covered with fibrin and exudative.
③ high occurs in 6-10 week-old broilers, and sudden death.
④ young chicks show vigor loss, loss of appetite with no obvious symptoms, anorexia, weakness and mortality.
⑤ because of symptoms such as white or yellow-green diarrhea and abdominal distension can be mistaken for pullorum.
 
3) Omphalitis
① In the breeders, ovarian infection or salpingitis can be caused by E. coli could be entered to the egg.
② Omphalitis occurs after yolk is not absorbed properly, it may cause inflammation and swelling belly and eventually mortality.

4) Enteritis
① colitis cause of diarrhea and attached a lot of mucus on the intestines.
② hemorrhagic enteritis with high mortality at 10 weeks of age is observed and the necropsy was found of bleeding and ulcers on the intestinal mucosal surface.
 
5) Salpingitis
① E. coli in the abdominal cavity receives the proceeds from air sacculitis into peritonitis, and gradually develop into a chronic salpingitis.
② layer is no particular symptoms, is expanded by the exudation of cheese shaped in the oviduct and stinks.
③ secretions, such as egg white is the oviduct is closed, so that condensation ovulation the yolk falls into the abdominal cavity.
 
6) E. coli granuloma
Small intestine, cecum, mesentery and the liver appears nodular granulomatous lesions.
 
7) Arthritis and Joint Synovitis
① swelling around the joint and the limping and lying at an angle.
② contains substances such as cheese within the joint sac.
 
8) Panophthalmitis
① eyelid swelling comes and tears the efflorescence puts the pupil.
② corneal opacities, and retinal detachment can become blindness.
 
4. Prevention and Treatment
1) Prevention
① buy a chicken flocks absence of mycoplasma, subjected to viral respiratory disease vaccine.
② to conduct a proper ventilation in order to reduce damage to the respiratory tract and thorough disinfection and drug susceptibility tests must be performed when selected.
 

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