Take the infringement in Larynx, trachea, bronchi, conjunctiva, air sac then show dyspnea, coughing, gasping, blood exudate discharge, the acute or chronic infectious respiratory disease of chicken.
1. Agent
Virus as belonging to the Herpesviridae showing variable mortality and pathogenicity. This virus is easily lost their infectivity by the process of organic chemicals, such as chloroform or ether because they have outer membrane envelope and low resistant to the outside temperature, it is easily killed by the disinfectant.
2. Epidemiology
It is caused by acute as time goes by chronic phase then the pathogenicity are weaken and tend to occur on the persistency on the local level, and sometimes occurs as a acute trend by region. Transmission route are
① The virus invades the respiratory tract or the conjunctiva.
② Carrier system is infected with the virus will continue to respiratory tract.
③ Spread by Management equipment, vehicles and people entering and leaving the poultry farm, birds or mice.  
3. Clinical Signs
1) Chicken
① sudden mortality, conjunctivitis occurs in tears, nasal exudate mixed with mucus discharge.
② sound golgol as respiratory symptoms and breathing is so frustrating because blood sputum full in the trachea then hold up the neck height for carrying out drinking and respiration.
③ high temperature, loss of vigor, combs turns purple, and decreased appetite.
2) Chicks (Pullet)
① severe respiratory symptoms is less than chicken.
② conjunctivitis, coughing and panting, golgol and causes mild respiratory distress.
 
 
4. Prevention
1) Prevention
It must be carried out with hygienic specifications control and vaccination. The virus propagation is slow between the cage because it is weak to disinfectant that effective to block the virus. The virus inlet block and install the periodic disinfection of the poultry house, vehicle passway and scaffolding are effective.

2) Vaccination
Conduct at least four weeks for chickens and conduct a re-vaccination has to be used in layer.
 
 

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